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Serlogy Serologic tests are blood tests that look for antibodies in your blood. They can involve a number of laboratory techniques. Different types of serologic tests can diagnose various disease conditions. Serologic tests have one thing in common. They all focus on proteins made by your immune system. This vital body system helps keep you healthy by destroying foreign invaders that can make you ill. The process for having the test is the same regardless of which technique the laboratory uses during serologic testing.